Clinical Study on Acupuncture Treatment of Perennial Allergic Rhinitis (PAR) Based on Zelen’s Design


  • Zhi Qing Liu Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China
  • Hui Xie Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China;
  • Sha Sha Yang Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China
  • Qin Wei Fu Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China
  • Nan Xiang Chengdu First People’s Hospital, Chengdu, 610000, China
  • Qin Xiu Zhang Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China



Zelen’s design, Allergic rhinitis, Acupuncture, Traditional Chinese Medicine


Objective: Perennial allergic rhinitis (PAR) is clinically defined as an inflammatory condition of the nose characterised by nasal obstruction, sneezing, itching, or rhinorrhea, occurring for an hour or more on most days throughout the year. The study aimed to evaluate the effectiveness of acupuncture treatment for PAR.
Methods: 76 subjects were enrolled with inclusion criteria and randomly divided into the acupuncture group (AG) and drug group (DG) based on Zelen’s design. In AG, Yintang (EX-HN3), LI20 (bilateral), LI11 (left), LI4 (left), ST36 (bilateral) were selected as primary acupoints, and adjunct acupoints were added based on syndrome differentiation. Acupuncture treatment for four weeks was performed once every two days. In DG, Desloratadine Citrate Disodium tablet was administrated orally once every day for four weeks. The variations of total nasal symptom score (TNSS) and overall non-nasal symptom score (TNNSS) were tested within three days before, at Week-4 during, and at Week-4 (follow-up) after the treatment.
Results: Thirty-two subjects in the AG and 38 subjects in the DG completed the trial. The differences between TNSS and TNNSS scales in the same groups showed a statistical difference (P<0.05) before, during, and after the treatment. The statistic differences between TNSS and TNNSS in those two groups were not obtained (P>0.05) before and after the treatment. The differences in those two groups during the follow-up visit were statistically different (P<0.05).
Conclusion: Acupuncture could effectively control the nasal and systemic symptoms of PAR, and its effect was more persistent than the administration of Desloratadine Citrate Disodium.


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Cheng L, Chen JJ, Fu QL, He SH, Li HB, Liu Z, et al. Chinese society of allergy guidelines for diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res, 2018,10(4):300-353.

Han DM, Zhang L, Huang D, Wu YF, Dong Z, Xu G, et al. Self-reported prevalence of allergic rhinitis in 11 cities in China. Chin J Otorhinolaryngol Head Neck Surg, 2007, 42(5): 378-384.

Pawankar R, Mori S, Ozu C, Kimura S. Overview on the pathomechanisms of allergic rhinitis. Asia Pac Allergy, 2011,1(3):157-167.

Chen H, Hu HL, Song C, Liu XF, Yin W, Li XY, Hu Y. Prevalence and risk factors of uncontrolled allergic rhinitis. Chinese Otolaryngology Head and Neck Surgery, 2019, 26(1):321-341.

Bousquet PJ, Bachert C, Canonica GW, Casale TB, Mullol J, Klossek JM, et al. Uncontrolled allergic rhinitis during treatment and its impact on the quality of life: a cluster randomised trial. J Allergy Clin Immunol, 2010, 126(3):666-668.e5.

Yu MZ, Xuan LH. Study on the selection of acupuncture points for treating allergic rhinitis. Shanxi Univ Tradit Chin Med, 2016, 17(2): 15-16.

Shi ZH, Wang P, Chen S, Pu Y, Wang P, Wang YP, et al. Randomised controlled clinical study of Tiaoshen acupuncture on allergic rhinitis. J Beijing Univ Tradit Chin Med (Clinical Edition of Traditional Chinese Medicine), 2013, 20(2): 47-49.

Lai YM, Li XE, Wu HB, Gao S. Bee acupuncture therapy for allergic rhinitis in 30 cases. Guangxi Tradit Chin Med, 2017, 40(3): 33-35.

Zhao S, Fan Q, Qin ML, Li Q, Li J, Li S. Therapeutic observation on acupuncture moxibustion at different intervals for persistent allergic rhinitis. J Acupunct Tuina Sci,17: 409-415.

Wang P, Luo HLL, Sun JQ, Shi ZH, Zhao JP. Observation of the efficacy of “Tiaoshen Acupuncture” in treating 27 cases of moderate and severe allergic rhinitis.Tradit Chin Med, 2013, 54(24): 2117-2120.

Yan ZF, Jiao LL, Gong Z, Liu LL, Liu Sm, Liu Q, et al. Clinical observation of intranasal acupuncture combined with Yiqi Jiemin Decoction in treating 60 cases of moderate to severe allergic rhinitis with deficiency of lung Qi. Tradit Chin Med, 2018, 59(12): 1035-1038.

Liu TS, Qiu R, Lai XS. Observation on curative effect of treating perennial allergic rhinitis with three-needle nasal acupuncture based on syndrome differentiation. Chin Acupunct, 2014, 34(11): 1083-1086.

Zhen F, Shi MH. Observation on therapeutic effect of nasal three-needle therapy on allergic rhinitis. Shanghai. Acupunct Moxibust, 2015, 34(2): 125-127.

Rhinology Group of the editorial board of Chinese J Otorhinolaryngol Head Neck Surgery Magazine, Rhinology Group of J Otorhinolaryngol Head Neck Surgery Branch of Chinese Medical Association. Guidance of Diagnosing and Treating Allergic Rhinitis (2015, Tianjin). Chin J Otorhinolaryngol Head Neck Surg. 2016:51(1):6-18.

Liang FR, Wang Hua. Acupuncture and Moxibustion. Beijing: China Traditional Chinese Medicine Publishing House, 2016. 08.

Zeng L, Zhang H, Zhao YM. Zelen’s research and design brief introduction. Chin J Pediat, 2016,54(3):181

Tan XL, Zhang DJ, Jiang GQ, Chen HY, Lu L, Cheng SM, et al. Impact of case management on the cognitive function of patients with severe mental disorders: a randomised controlled study based on Zelen’s design. Ner Dis Ment Health, 2019, 4:348-352.

Pan YQ, Deng XZ. An experimental scheme and appraisal for network clients’ information retrieval behaviours. Lib Inf Serv, 2007(03): 76-79.

Zhang R, Rong B, Li J, Li XT. Effect of Xingnao Kaiqiao Acupuncture on non-dementia vascular cognitive impairment. Tradit Chin Med, 2019, 60(12): 1046-1050.

Liu TS, Qiu R, Lai XS. Curative effect observation for perennial allergic rhinitis cured by point selection by pattern identification of three nasal stitches as the main. Chin Acupunct Moxibust, 2014, 34 (11): 1083-1086.

Chen S, Wang J, Bai P, Zhao Q, Tan C, Wang BK, Zhang JJ, Zhao JP. Moderate-severe persistent allergic rhinitis of acupuncture treatment: a randomised controlled trial. Chin Acupunct Moxibust, 2015, 35 (12): 1209-1213.

Huang Y. Clinical study on treating allergic rhinitis with electro-acupuncture at Yingxiang point. Beijing University of Traditional Chinese Medicine, 2006.

Xing X, Jia HB, Xiao WG, Cui LH. Treatment of 133 cases of allergic rhinitis by electroacupuncture stimulation of bilateral Yingxiang points. Mod J Integrat Tradit Chin West Med, 2011, 20(18): 2282-2283.

Chen M. Acupoint injection of Yingxiang acupoint for treatment of allergic rhinitis. Clin Acupunct Moxibust, 2006(12):44.

Han W,Yang JA. Multi-center study on the effectiveness of Yintang point in the treatment of allergic rhinitis. Clin J Tradit Chin Med,2007,19(4)392-394.

Wang HR. Chronic Rhinitis Treated by Acupuncture at Yintang and Chengjiang. Sichuan Tradit Chin Med, 2008, 26 (10): 108-109.

Liu Y, Hu DY, Gao L, Gong M, Tong BY, Lin D, et al. Study on distribution law of pain-sensitive points and heat-sensitive points in allergic rhinitis patients. Acupunct Res, 2019, 44(11):826-831.

Yang RG, Ma ZX, Zhou MY, Long LJ, Tu ZS. Observation on therapeutic effect of triamcinolone acetonide injection on 30 cases of seasonal allergic rhinitis. Guiyang Univ Tradit Chin Med, 2013, 35(04): 280- 281.

Du CH. Sixty cases of allergic rhinitis treated by drug injection at Quchi point. Mod Integrat Tradit Chin West Med, 2008, 17(20):3163.

Zheng MF, He FR, Wu MX, Zheng LP. Effect of acupuncture on different points of yangming channel on allergic rhinitis. Shanghai J Acupunc, 2011, 30 (1): 35-37.



How to Cite

Liu, Zhi Qing, Hui Xie, Sha Sha Yang, Qin Wei Fu, Nan Xiang, and Qin Xiu Zhang. 2020. “Clinical Study on Acupuncture Treatment of Perennial Allergic Rhinitis (PAR) Based on Zelen’s Design”. Annals of Chinese Medicine 2020 (1):9.



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